個人簡介

 
中文姓名： 廖文峯 wfliaw
英文姓名： Liaw, Wen-Feng
電子郵件： wfliaw@mx.nthu.edu.tw
聯絡電話： 03-5715131 #35663
傳真： 03-5711082
辦公室位置： 化學館 R726
研究專長 無機化學、生化學程

 

研究興趣

 

Current studies include the synthesis of biomimetic model compounds of metalloenzyme active sites. Of particular interest is directed at the bioinspired coordination Chemistry, i.e., small molecules (CO2, N2O, O2, H2, S8, NO2-, NO3-) activation by Ni-/Fe-containing complexes. The synthesis of dinitrosyl iron complexes (DNICs) and NO trapping agents, and the biomimetically synthesized iron-nitrite and -thionitrite compounds ([(NO)nFe-NO2] and [Fe-(RSNO)]) are of particular interest in the ongoing studies of transition metal-NO chemistry. Another major efforts involve biomimetic model study on the synthesis of the anionic/neutral/cationic {Fe(NO)}9/{Fe(NO)}10 S/N/O-bound dinitrosyl iron compounds (DNICs), interconversion among anionic/neutral/cationic {Fe(NO)}9, neutral {Fe(NO)10 dinitrosyl iron compounds, Roussin’s red ester, anionic Roussin’s red ester, and degradation/reassembly of the [Fe-S] cluster, respectively.  Studies are being carried out to determine the oxidation states of metal and NO by XAS, EPR and SQUID.

 

期刊著作

 

1. Wen-Feng Liaw,* Wen-Ting Tsai, Hung-Bin Gau, Chien-Ming Lee, Shin-Yuan Chou, Wen-Yuan Chen, Gene-Hsiang Lee “Dinuclear Iron(II)-Cyanocarbonyl Complexes Linked by Two/Three Bridging Ethylthiolates: Relevance to the Active-Site of [Fe] Hydrogenases” Inorg. Chem. 2003, 42, 2783-2788.


2. Chung-Hung Hsieh, I-Jui Hsu, Chien-Ming Lee, Shyue-Chu Ke,* Tze-Yuan Wang, Gene-Hsiang Lee, Yu Wang,* Jin-Ming Chen, Jyh-Fu Lee, Wen-Feng Liaw* “Nickel Complexes of o-amidochalcogenophenolate(2-)/o-iminochalcogenobenzo semiquinonate(1-) -radical: Synthesis, Structures, Electron Spin Resonance and X-ray Absorption Spectroscopic Evidence” Inorg. Chem. 2003, 42, 3925-3933.


3. Chien-Ming Lee, Chung-Hung Hsieh, Amitava Dutta, Gene-Hsiang Lee,
Wen-Feng Liaw* “Reversible Oxygen Binding to Sulfur in Nitrosylated Iron- Thiolate Complexes: Relevance to the Fe-Containing Nitrile Hydratases” J. Am. Chem. Soc. 2003, 125, 11492-11493.


4. Chien-Hong Chen, Yung-Su Chang, Chien-Yeh Yang, Tai-Nan Chen, Chien-Ming
Lee, Wen-Feng Liaw* “Preparative and Structural Studies on Iron(II)-Thiolate Cyanocarbonyls: Relevance to the [NiFe]/[Fe]-Hydrogenases” Dalton Trans. 2004, 137-143.


5. Chien-Ming Lee, Chien-Hong Chen, Shyue-Chu Ke,* Gene-Hsiang Lee, Wen-Feng Liaw* “Mononuclear Nickel(III) and Nickel(II) Thiolate Complexes with Intramolecular S-H Proton Interacting with Both Sulfur and Nickel: Relevance to the [NiFe]/[NiFeSe] Hydrogeanses” J. Am. Chem. Soc. 2004, 126, 8406-8412.


6. Ming-Li Tsai, Chiao-Chun Chen, I-Jui Hsu, Shyue-Chu Ke,* Chung-Hung Hsieh, Kuo-An Chiang, Gene-Hsiang Lee, Yu Wang,* Wen-Feng Liaw* “Photochemistry of the Dinitrosyl Iron Complex [S5Fe(NO)2]- Leading to Reversible Formation of [S5Fe(µ-S)2FeS5]2-: Spectroscopic Characterization of Species Relevant to the Nitric Oxide Modification and Repair of [2Fe-2S] Ferredoxins” Inorg. Chem. 2004, 43, 5159-5167.


7. Chien-Hong Chen, Li-Chun Wang, Wen-Feng Liaw* “Preparative and Structural Studies on Ruthenium(II)-Thiolate Cyanocarbonyls: Comparison to the [Fe(CO)x(CN)y(SR)z]n- Coordination Modes of Active Sites of Hydrogenases” J. Chin. Chem. Soc. 2004, 51, 1121-1126.


8. Hao-Wen Chen, Chin-Wei Lin, Chiao-Chun Chen, Li-Bo Yang, Ming-Hsi Chiang, Wen-Feng Liaw* “Homodinuclear Iron-Thiolate Nitrosyl Compounds [(ON)Fe(S,S-C6H4)2Fe(NO)2]— and [(ON)Fe(SO2,S-C6H4)(S,S-C6H4)Fe(NO)2]— with {Fe(NO)}7-{Fe(NO)2}9 Electronic Coupling: New Members of A Class of Dinitrosyl Iron Complexes” Inorg. Chem. 2005, 44, 3226-3232.


9. Fu-Te Tsai, Show-Jen Chiou, Ming-Che Tsai, Ming-Li Tsai, Hsiao-Wen Huang, Ming-Hsi Chiang, Wen-Feng Liaw* “Dinitrosyl Iron Complexes (DNICs) [L2Fe(NO)2]– (L = Thiolate): Interconversion among {Fe(NO)2}9 DNICs, {Fe(NO)2}10 DNICs and [2Fe-2S] Clusters, and the Critical Role of the Thiolate Ligands in Regulating NO Release of DNICs” Inorg. Chem. 2005, 44, 5872-5881.


10. Chien-Ming Lee, Chien-Hong Chen, Hao-Wen Chen, Jo-Lu Hsu, Gene-Hsiang Lee, Wen-Feng Liaw* “Nitrosylated Iron-Thiolate-Sulfinate Complexes with {Fe(NO)}6/7 Electronic Cores: Relevance to the Transformation between the Active and Inactive NO-Bound Forms of Fe-Containing Nitrile Hydratases” Inorg. Chem. 2005, 44, 6670-6679.


11. Wen-Feng Liaw, “Nickel: Models of Protein Active Sites” In Encyclopedia of
Inorganic Chemistry, Second Edition., Robert A. Scott, Eds.; John Wiley & Sons: 2005.


12. Chien-Hong Chen, Gene-Hsiang Lee, Wen-Feng Liaw* “Mononuclear [NiII(L)(P-(o-C6H4S)2(o-C6H4SH))]0/1– (L = Thiolate, Selenolate, PPh3, and Cl) Complexes with Intramolecular [Ni－S…H－S]/[Ni…H－S] Interactions Modulated by the Coordinated Ligand L: Relevance to the [NiFe] Hydrogenases” Inorg. Chem. 2006, 45, 2307-2316.


13. Tai-Nan Chen, Feng-Chun Lo, Ming-Li Tsai, Ko-Nien Shih,* Ming-Hsi Chiang, Gene-Hsiang Lee, Wen-Feng Liaw* “Dinitrosyl iron complexes [E5Fe(NO)2]– (E = S, Se): a precursor of Roussin’s black salt [Fe4E3(NO)7]–” Inorg. Chimi. Acta 2006, 359, 2525-2533.


14. Mu-Cheng Hung, Ming-Che Tsai, Gene-Hsiang Lee, Wen-Feng Liaw* “Transformation and Structural Discrimination between the Neutral {Fe(NO)2}10 Dinitrosyl Iron Complexes (DNICs) and the Anionic/Cationic {Fe(NO)2}9 DNICs ” Inorg. Chem. 2006, 45, 6041-6047.


15. Ming-Li Tsai, Wen-Feng Liaw* “Neutral {Fe(NO)2}9 Dinitosyl Iron Complex (DNIC) [(SC6H4-o-NHCOPh)(Im)Fe(NO)2] (Im = imidazole): Interconversion among the Anionic/Neutral {Fe(NO)2}9 DNICs and Roussin’s Red Ester ”
Inorg. Chem. 2006, 45, 6583-6585.


16. Tsai-Te Lu, Show-Jen Chiou, Chun-Yu Chen, Wen-Feng Liaw* “Mononitrosyl Tris(Thiolate) Iron Complex [Fe(NO)(SPh)3]– and Dinitrosyl Iron Complex [(EtS)2Fe(NO)2]–: Formation Pathway of Dinitrosyl Iron Complexes (DNICs) from Nitrosyltion of Biomimetic Rubredoxin [Fe(SR)4]2–/1– (R = Ph, Et)”
Inorg. Chem. 2006, 45, 8799-8806.


17. Chien-Ming Lee, Ya-Lan Chuang, Chao-Yi Chiang, Gene-Hsiang Lee, Wen-Feng Liaw* “Mononuclear Ni(III) Complexes [NiIII(L)(P(C6H3-3-SiMe3-2-S)3)]0/1– (L = Thiolate, Selenolate, CH2CN, Cl, PPh3): Relevance to the Nickel Site of [NiFe] Hydrogenases“ Inorg. Chem. 2006, 45, 10895-10904.


18. I-Jui Hsu, Chung-Hung Hsieh, Shyue-Chu Ke,* Kuo-An Chiang, Jenn-Min Lee, Jin-Ming Chen, Ling-Yun Jang, Gene-Hsiang Lee, Yu Wang,* Wen-Feng Liaw* “New Members of A Class of Iron-Thiolate-Nitrosyl Compounds: Trinuclear Iron-Thiolate-Nitrosyl Complexes Containing Fe3S6 Core” J. Am. Chem. Soc. 2007, 129, 1151-1159.


19. Ming-Li Tsai, Chung-Hung Hsieh, Wen-Feng Liaw* “Dinitrosyl Iron Complexes (DNICs) Containing S/N/O Ligation: Transformation of Roussin's Red Ester into the Neutral {Fe(NO)2}10 DNICs” Inorg. Chem. 2007, 46, 5110-5117.


20. Chih-Chin Tsou, Tsai-Te Lu, Wen-Feng Liaw* “EPR, UV-vis, IR and X-ray Demonstration of the Anionic Dimeric Dinitrosyl Iron Complex [(NO)2Fe(µ- StBu)2Fe(NO)2]–: Relevance to the Products of Nitrosylation of Cytosolic and Mitochondrial Aconitases, and High-Potential Iron Proteins”
J. Am. Chem. Soc. 2007, 129, 12626-12627.


21. Chien-Ming Lee, Tzung-Wen Chiou, Hsin-Hung Chen, Chao-Yi Chiang, Ting-Shen Kuo,‡ Wen-Feng Liaw* “Mononuclear Ni(II)-Thiolate Complexes with Pendant Thiol and Dinuclear Ni(III/II)-Thiolate Complexes with Ni…Ni Interaction Regulated by the Oxidation Levels of Nickels and the Coordinated Ligands” Inorg. Chem. 2007, 46, 8913-8923.


22. Hsiao-Wen Huang, Chih-Chin Tsou, Ting-Shen Kuo, Wen-Feng Liaw* “New Members of a Class of Dinitrosyl Iron Complexes (DNICs):
Interconversion and Spectroscopic Discrimination of the Anionic {Fe(NO)2}9 [(NO)2Fe(C3H3N2)2]– and [(NO)2Fe(C3H3N2)(SR)]– (C3H3N2 = Deprotonated Imidazole ; R = tBu, Et, Ph)” Inorg. Chem. 2008, 47, 2196-2204.


23. Tsai-Te Lu, Chih-Chin Tsou, Hsiao-Wen Huang, I-Jui Hsu, Jin-Ming Chen, Ting-Shen Kuo, Yu Wang,* Wen-Feng Liaw* “Anionic Roussin’s Red Esters (RREs) syn-/anti-[Fe(μ-SEt)(NO)2]2–: the Critical Role of Thiolate Ligands in Regulating the Transformation of RREs into Dinitrosyl Iron Complexes (DNICs) and the Anionic RREs” Inorg. Chem. 2008, 47, 6040-6050.


24. Tzung-Wen Chiou, Wen-Feng Liaw* “Mononuclear Nickel(III) Complexes [NiIII(OR)(P(C6H3-3-SiMe3-2-S)3)]1– (R = Me, Ph) Containing the Terminal Alkoxide Ligand: Relevance to the Nickel Site of Oxidized-Form [NiFe] Hydrogenases” Inorg. Chem. 2008, 47, 7909-7913.


25. Tzung-Wen Chiou, Wen-Feng Liaw* “Nickel-Thiolate and Iron-Thiolate Cyanocarbonyl Complexes: Modeling the Nickel and Iron Sites of [NiFe] Hydrogenase” C. R.. Chimie 2008, 11, 818-833. (Invited Review).


26. Feng-Chun Lo, Chang-Li Chen, Chien-Ming Lee, Ming-Che Tsai, Tsai-Te Lu, Wen-Feng Liaw, Steve S.-F. Yu* “A study of NO trafficking from dinitrosyl-iron complexes to the recombinant E. coli transcriptional factor SoxR” J. Biol. Inorg. Chem. 2008, 13, 961-972.


27. Yi-Ju Chen, Wei-Chi Ku, Li-Ting Feng, Ming-Li Tsai, Chung-Hung Hsieh, Wen-Hwei Hsu, Wen-Feng Liaw, Chen-Hsiung Hung,* Yu-Ju Chen* “Nitric oxide physiological responses and delivery mechanisms probed by water-soluble Roussin’s Red Ester and {Fe(NO)2}10 DNIC” J. Am. Chem. Soc. 2008, 130, 10929-10938.


28. Chia-Huei Lin, Chien-Ge Chen, Ming-Li Tsai, Gene-Hsiang Lee, Wen-Feng Liaw*
“Monoanionic {Mn(NO)}5 and Dianionic {Mn(NO)}6 Thiolato Nitrosyl Manganese Complexes: [(NO)Mn(L)2]– and [(NO)Mn(L)2]2– (LH2 = 1,2-Benzenedithiol and Toluene-3,4-Dithiol)” Inorg. Chem. 2008, 47, 11435-11443.


29. Chih-Chin Tsou, Zong-Sian Lin, Tsai-Te Lu, Wen-Feng Liaw* “Transformation of Dinitrosyl Iron Complexes (DNICs) [(NO)2Fe(SR)2]– (R = Et, Ph) into [4Fe-4S] Clusters [Fe4S4(SR)4]2–: Relevance to the Repair of the Nitric Oxide-Modified Ferredoxin [4Fe-4S] Clusters” J. Am. Chem. Soc. 2008, 130, 17154-17160.


30. Fu-Te Tsai, Ting-Shen Kuo, Wen-Feng Liaw* “Reversible Transformation between the Six-Coordinate {Fe(NO)2}9 [(η2-ONO)(1-MeIm)2Fe(NO)2] (g = 2.013) and Four-Coordinate {Fe(NO)2}9 [(ONO)(1-MeIm)Fe(NO)2] (g = 2.03)” Submitted to J. Am. Chem. Soc. 2009, 131, 3426-3427.


31. Tsai-Te Lu, Hsiao-Wen Huang, Wen-Feng Liaw “ Anionic Mixed Thiolate- Sulfide-Bridged Roussin’s Red Esters [(NO)2Fe(μ-SR)(μ-S)Fe(NO)2]– (R = Et, Me, Ph): A Key Intermediate for Transformation of Dinitrosyl Iron Complexes (DNICs) to [2Fe-2S] Clusters “ Inorg. Chem. 2009, 48, 9027-9035.


32. Ming-Che Tsai, Fu-Te Tsai, Tsai-Te Lu, Ming-Li Tsai, Yin-Ching Wei, I-Jui Hsu, Jyh-Fu Lee, Wen-Feng Liaw “Relative Binding Affinity of Thiolate, Imidazolate, Phenoxide and Nitrite Toward {Fe(NO)2} Motif of Dinitrosyl Iron Complexes (DNICs) : the Characteristic Pre-edge Energy of {Fe(NO)2}9 DNICs” Inorg. Chem. 2009, 48, 9579-9591.